Cannabichromene Anti-cancer Study
Aug 11, 2025
Cannabichromene (CBC) Anti-Cancer Research: Key Findings and Mechanisms
Cannabichromene (CBC), a non-psychoactive phytocannabinoid derived from Cannabis sativa, has emerged as a promising candidate for cancer therapy. Below is a synthesis of its anti-cancer properties and mechanisms based on recent studies:
Anticancer Mechanisms
Induction of Cell Death Pathways:
Apoptosis: CBC activates caspase-3/8/9, triggering programmed cell death in pancreatic, breast, and bladder cancer cells
Ferroptosis: Upregulates ferroptosis-related genes (e.g., HMOX1) and depletes glutathione, leading to lipid peroxidation in pancreatic cancer models
Autophagy: Modulates LC3-II and Beclin-1 expression, promoting cancer cell self-destruction
Receptor Modulation...