Can Olivetol treat obesity？

Yes. Olivetol treatment demonstrated ​​dose-dependent reductions in triglycerides, cholesterol biosynthesis (via HMG-CoA reductase suppression), and hepatic lipid accumulation​​, effectively ameliorating obesity-induced steatohepatitis. This was corroborated by normalized liver enzyme levels (ALT/AST), indicating significant hepatoprotective effects. These findings establish Olivetol's multi-target therapeutic potential against metabolic dysregulation in obesity, though further research is required to delineate its primary mechanistic actions – including possible synergistic effects with endogenous regulatory pathways – prior to clinical translation.

Figure 1. Olivetol

Olivetol exhibits a ​​divergent dose-response​​: low doses reduce hepatic enzymes (hepatoprotective potential), while high doses elevate HMG-CoA (cholesterol biosynthesis modulation). This supports its candidacy as an ​​anti-obesity therapeutic for hyperlipidemia-related disorders​​, necessitating further mechanistic and safety studies.¹

Reference

1.Andukuri Reshma, T.Tamilanban, V. Chitra. et al. Anti‑obesity efects of olivetol in adult zebrafish model induced by short‑term high‑fat diet. Scientifc Reports (2023) 13:18449. https://doi.org/10.1038/s41598-023-44462-3