Can Olivetol treat obesity?
May 11, 2024
Yes. Olivetol treatment demonstrated dose-dependent reductions in triglycerides, cholesterol biosynthesis (via HMG-CoA reductase suppression), and hepatic lipid accumulation, effectively ameliorating obesity-induced steatohepatitis. This was corroborated by normalized liver enzyme levels (ALT/AST), indicating significant hepatoprotective effects. These findings establish Olivetol's multi-target therapeutic potential against metabolic dysregulation in obesity, though further research is required to delineate its primary mechanistic actions – including possible synergistic effects with endogenous regulatory pathways – prior to clinical translation.
Figure 1. Olivetol
Olivetol exhibits a divergent dose-response: low doses reduce hepatic enzymes (hepatoprotecti...