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CAS 20675-51-8​​ CBC,99%

CAS 20675-51-8​​ CBC,99%

Cannabichromene (CBC) (CAS 20675-51-8)​​ is a non-psychoactive cannabinoid recognized for its potential synergistic role in the "entourage effect" and its distinct pharmacological profile. Unlike THC, it does not bind strongly to CB1 receptors but interacts with other targets such as TRPV and serotonin receptors, contributing to its studied anti-inflammatory, antimicrobial, and neurogenesis-promoting properties. Though typically found in low concentrations in cannabis cultivars, its emerging therapeutic potential makes it a compound of growing interest in neurological and inflammatory disorder research.

 

  • Name :

    Cannabichromene (CBC)
  • CAS No. :

    20675-51-8​​
  • MF :

    C₂₁H₃₀O₂
  • MW :

    314.46
  • Purity :

    99%
  • Appearance :

    Oil or crystalline solid (depending on purity)
  • Storage Condition :

    -20°C in airtight containers, protected from light

Chemical Properties

​​Molecular Formula​​: C₂₁H₃₀O₂

​​Molecular Weight​​: 314.46 g/mol

​​CAS Number​​: 20675-51-8

​​Appearance​​: Oil or crystalline solid (depending on purity) 

​​Melting Point​​: ~145°C 

​​Boiling Point​​: ~394°C (estimated) 

​​Solubility​​: Soluble in chloroform, dichloromethane, ethanol, DMSO, and acetone; sparingly soluble in water 

​​LogP​​: 8.56 (highly lipophilic) 

 

Biological Activities

​​Antimicrobial​​: Exhibits strong activity against antibiotic-resistant bacteria (e.g., MRSA) 

​​Anti-inflammatory​​: Modulates TRPV1 and TRPA1 receptors, reducing pain perception and inflammation 

​​Neuroprotective​​: Promotes neurogenesis and protects against neurodegenerative diseases (e.g., Alzheimer’s) in preclinical studies 

​​Antidepressant-like Effects​​: Enhances serotonin and dopamine signaling in rodents 

.

Applications

​​Pharmaceutical Research​​: Investigated for pain management, neurodegenerative disorders, and antimicrobial therapies 

​​Cannabinoid Products​​: Used in "full-spectrum" CBD formulations due to synergistic effects with other cannabinoids (entourage effect) 

​​Analytical Standards​​: Certified reference material (CRM) for HPLC/MS testing in cannabis potency analysis 

Synthesis and Production

​​Synthesis Pathway​​: Derived from cannabigerolic acid (CBGA) via enzymatic cyclization.

CBC modulates physiological responses by engaging with a variety of cell
surface receptors. Cannabinoid receptors 1 and 2 (CB1 and CB2, respectively)
are the canonical cannabinoid receptors in the body. CB1 functions primarily
in the central and peripheral nervous systems, and its engagement via
∆9-THC results in psychoactive effects. CB2 is primarily found in the
peripheral nervous system and in immune system tissues [4].
Signaling through CB2 modulates inflammation and other aspects of immune system function.
CBC was recently found to bind CB2 rather than CB1 [5], suggesting
a role in pain reduction and modulation of the immune system response.prevent crystallization.
 
 
 
 

 

Shipment Guidelines

  • #
    Packaging Requirements​​
    Primary Packaging​​: Must be airtight, moisture-proof containers to prevent oxidation and humidity exposure. 
    ​​Secondary Packaging​​: Use shockproof materials to avoid physical damage during transit.

    ​​Labeling​​: Include hazard symbols CAS number, and "Keep Away from Heat/Incompatible Substances" warnings.

  • #
    Logistics Providers & Modes​​

    Air Freight​​: Preferred for urgent shipments; ensure packages meet IATA Dangerous Goods Regulations (DGR) for organic peroxides.

    ​​Shipping Modes​​:

    ​​Expedited​​: 3–5 business days (e.g., DHL Express) for time-sensitive research projects.

    ​​Standard​​: 7–14 days via sea freight, cost-effective for bulk orders.

  • #
    Temperature & Stability Control​​

    ​​Storage Conditions​​:

    Pre-Shipment​​: Store at 2–8°C if light-sensitive; avoid freezing to prevent crystallization.

    ​​In Transit​​: Maintain ambient temperature (15–25°C) with humidity <60%. Use data loggers for real-time monitoring.

    ​​Risk Mitigation​​: Include desiccants and oxygen absorbers in packaging. Avoid prolonged exposure to sunlight or electromagnetic fields.

-

FAQ

Q: What is Cannabichromene (CBC)?​

A: Definition​​: CBC is a non-intoxicating phytocannabinoid derived from the cannabis plant, chemically synthesized from ​​cannabigerolic acid (CBGA)​​. Its molecular formula is ​​C₂₁H₃₀O₂​​, and it shares structural similarities with THC and CBD but binds to distinct receptors

Q:  Is CBC safe?​

A: Side Effects​​: Mild (dry mouth, fatigue, dizziness) at low doses; rare gastrointestinal issues 

​​Toxicity​​: No significant acute toxicity in rodents; safe up to 20 mg/kg in mice 

​​Drug Interactions​​: May inhibit CYP450 enzymes, affecting drug metabolism (e.g., anticoagulants) 

​​Q: CBC vs. Cannabicyclol (CBL)​

A: CBC decarboxylates into ​​CBL​​ (a minor cannabinoid), but CBL lacks CBC’s therapeutic activity.

​​Q: Future Research Directions​?​​

A: Chirality​​: Studying (-)-CBC’s superior CB2 receptor activation over (+)-CBC 

.Cancer Therapy​​: Combining CBC with temozolomide to enhance tumor suppression .

Skin Health​​: Developing CBC-based acne treatments .

 

 

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