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98% Purity Cannabigerol ​​(CBG) CAS 25654-31-3

98% Purity Cannabigerol ​​(CBG) CAS 25654-31-3

Cannabigerol  ​​(CBG) (CAS 25654-31-3)​​ is a non-psychoactive cannabinoid often referred to as the "mother cannabinoid" or "stem cell cannabinoid" because it serves as the direct biosynthetic precursor to other major cannabinoids like THC, CBD, and CBC in the cannabis plant. Though typically present in low concentrations in most cultivars, it exhibits a broad pharmacological profile, interacting with CB1, CB2, and other receptors, and is researched for its potential anti-inflammatory, antimicrobial, and neuroprotective properties. Its critical role in cannabinoid biosynthesis and its emerging therapeutic promise make it a high-value compound for both agricultural and pharmaceutical development.

  • Name :

    Cannabigerol
  • CAS No. :

    25654-31-3
  • MF :

    C₂₁H₃₂O₂
  • MW :

    316.48
  • Purity :

    98%
  • Appearance :

    White to off-white crystalline powder
  • Storage Condition :

    Sparingly soluble in ethanol and DMSO; insoluble in water

Chemical Properties

​​Chemical Name​​:Cannabigerol 

CAS Number​​: 25654-31-3

​​Synonyms​​:CBG

​​Molecular Formula​​: C₂₁H₃₂O₂

​​Molecular Weight​​: 316.48 g/mol

​​Appearance​​: White to off-white crystalline powder

​​Melting Point​​: 49–50°C

​​Boiling Point​​: 470.4 ± 40.0°C (predicted)

​​Density​​: 0.987 ± 0.06 g/cm³ (predicted)

​​Solubility​​: Sparingly soluble in ethanol and DMSO; insoluble in water 

​​pKa​​: 9.71 ± 0.40 (predicted)

​​SMILES Notation​​: C1(O)=CC(CCCCC)=CC(O)=C1C/C=C(\C)/CC/C=C(\C)\C

​​InChI​​: InChI=1S/C21H32O2/c1-5-6-7-11-18-14-20(22)19(21(23)15-18)13-12-17(4)10-8-9-16(2)3/h9,12,14-15,22-23H,5-8,10-11,13H2,1-2H3

 

Biological and Pharmacological Roles

CBG is a ​​non-psychoactive cannabinoid​​ found in Cannabis sativaand Helichrysumspecies.

Key roles include:

​​Anti-Inflammatory​​: Reduces cytokine release (e.g., IL-1β, TNF-α) in UV-induced skin inflammation .

​​Neuroprotective​​: Improves motor deficits and protects neurons in Huntington’s and Alzheimer’s models .

​​Antimicrobial​​: Effective against Methicillin-resistant Staphylococcus aureus (MRSA), comparable to vancomycin .

​​Analgesic​​: Alleviates neuropathic pain in rodent models .

​​Anticancer​​: Inhibits colon cancer cell proliferation and enhances chemotherapy efficacy .

​​Glaucoma Relief​​: Reduces intraocular pressure by modulating cannabinoid receptors .

 

Mechanism of Action

​​Receptor Interaction​​: Partial agonist of CB₁/CB₂ receptors (Ki = 337/440 nM) and α₂-adrenoceptor agonist (EC₅₀ = 0.2 nM) .

​​Enzyme Modulation​​: Inhibits FAAH, enhancing anandamide signaling .

​​ROS Scavenging​​: Reduces oxidative stress in human dermal fibroblasts .

 

Medical Application

 

Synthesis and Prouction

​​Natural Extraction​​: Isolated from cannabis trichomes, but yields are <1% .

​​Yeast Biosynthesis​​: Engineered yeast strains produce CBG sustainably at scale .

​​Chemical Synthesis​​: Requires multi-step processes from cannabigerolic acid (CBGA) .

 

Commercial and Research Use

​​Topical Formulations​​: Serums and creams for anti-aging and acne (e.g., 0.1% CBG formulations) .

​​Clinical Trials​​: Phase I studies for psoriasis and neuropathic pain .

​​Supplements​​: Available as oils, capsules, and edibles for systemic effects .

 

FAQ

Q1: What is CBG and how is it different from CBD or THC?​​
​A:​​ CBG is a non-psychoactive "parent cannabinoid" that serves as the biosynthetic precursor to CBD, THC, and other cannabinoids. Unlike THC, it does not induce intoxication, and unlike CBD, it interacts more directly with both CB1 and CB2 receptors while retaining a distinct pharmacological profile.
​Q2: Why is CBG typically more expensive than other cannabinoids?​​
​A:​​ CBG is naturally produced in very low concentrations (<1%) in most cannabis plants, requiring specialized cultivation, advanced extraction techniques, and larger biomass volumes to isolate meaningful quantities, thereby increasing production costs.
​Q3: What are the key research applications for CBG?​​
​A:​​ Current research focuses on its potential anti-inflammatory, antimicrobial, and neuroprotective properties, as well as its role in studying cannabinoid biosynthesis pathways and receptor interactions. It is also explored for glaucoma, inflammatory bowel disease, and cancer-related applications.
​Q4: How should CBG be stored to ensure stability?​​
​A:​​ Store CBG in a sealed container under inert gas (e.g., N₂ or Argon) at low temperatures (–20°C) and protect it from light to prevent oxidation and degradation, which could alter its purity and efficacy.
​Q5: Is CBG legal for research and commercial use?​​
​A:​​ Legal status varies by jurisdiction. In many regions, CBG derived from hemp (containing <0.3% THC) is legal, but regulations evolve rapidly. Always verify local laws and compliance requirements before procurement or use.
Q6: What are the key differences between CBG and CBD in terms of medical applications?
A: Choose CBG​​ for:
     Acute anxiety, neuroprotection, or antimicrobial needs.
     Patients seeking daytime energy or digestive support.
​​Choose CBD​​ for:
     Chronic pain, sleep disorders, or epilepsy.
      Budget-conscious users or those prioritizing long-term relaxation.
For synergistic effects, consider ​​CBG-CBD blends​​ (e.g., tinctures or edibles) to leverage both rapid action and sustained benefits.
Always consult a healthcare provider, especially if combining with medications

 

 

 
 

 

 

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