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98% Purity Olivetolic Acid CAS 491-72-5

CAS 491-72-5 Olivetolic Acid Global Supplier

98% Purity Olivetolic Acid CAS 491-72-5

Olivetolic Acid (CAS No.491-72-5) is a polyketide compound with significant biological and industrial applications. Below is a detailed overview of its properties and uses.

Name :
Olivetolic acid
CAS No. :
491-72-5
MF :
C₁₂H₁₆O₄
MW :
224.25
Purity :
98%
Appearance :
Off white powder
Storage Condition :
Sealed in dry, Room Temperature

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Chemical Properties

Formal Name	2,4-Dihydroxy-6-pentylbenzoic acid
Synonyms	OA；OLA；Olivetolate；Olivetolcarboxylic Acid；Allazetolcarboxylic acid
CAS Number	491-72-5
Molecular Formula	C₁₂H₁₆O₄
Formula Weight	224.25 g/mol

Structure:

A benzoic acid derivative with hydroxyl (-OH) and pentyl (-C₅H₁₁) substituents at the 2nd and 4th positions, respectively.

Physical Characteristics:

Appearance: Off white powder

Melting point:143 °C

Boiling Point: 403.9±25.0 °C(Predicted)

Density: 1.237±0.06 g/cm3(Predicted)

Solubility: DMSO (Slightly), Methanol (Slightly)

Biological Activities

Precursor in Cannabinoid Synthesis:Olivetolic Acid is the psychoactive component of Cannabis sativa.It condenses with geranyl pyrophosphate to form cannabigerolic acid (CBGA), the precursor to other cannabinoids

Antimicrobial and Antioxidant Properties:Exhibits antimicrobial activity against certain bacterial strains and antioxidant effects, contributing to its potential in pharmaceutical formulations

Anti-Inflammatory and Neuroprotective Effects:Emerging research highlights its role in reducing inflammation and protecting neuronal cells, suggesting applications in neurodegenerative diseases.

Biosynthesis

Pathway: Produced via a polyketide synthase (PKS) pathway in Cannabis sativa:

Condensation: Hexanoyl-CoA and three malonyl-CoA units are combined by tetraketide synthase (CsOLS).

Cyclization: Olivetolic acid cyclase (CsOAC) forms the aromatic ring structure

Microbial Production: Engineered Yarrowia lipolyticaand E. colistrains have achieved trace OA synthesis by optimizing acyl-CoA synthesis and carbon flux redirection

Applications

Pharmaceuticals:

Core Cannabinoid Synthesis:Precursor in Cannabinoid Synthesis.Olivetolic Acid is the psychoactive component of Cannabis sativa.It condenses with geranyl pyrophosphate to form cannabigerolic acid (CBGA), the precursor to other cannabinoids.

Drug Discovery Scaffold:PPARγ Agonists;Anti-Inflammatory Agents;Neuroprotectants

Cosmetics: Anti-Aging Formulations;Skin Brightening;Acne Treatments

Biotechnology & Metabolic Engineering:Cannabinoid Pathway Optimization；Biosensor Design

Agriculture: Plant Defense Elicitor;Eco-Friendly Pesticides

Research Tools:Analytical Reference Standard；Metabolic Pathway Studies

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Reducing energy consumption by 20% compared to industry averages.

Advanced Production Techniques
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Digital Transformation
Integration of AI-driven systems optimizes production efficiency and enables predictive maintenance.

Shipment Guidelines

Packaging Requirements
Primary Packaging: Must be airtight, moisture-proof containers to prevent oxidation and humidity exposure.

Secondary Packaging: Use shockproof materials to avoid physical damage during transit.

Labeling: Include hazard symbols CAS number, and "Keep Away from Heat/Incompatible Substances" warnings.
Logistics Providers & Modes

Air Freight: Preferred for urgent shipments; ensure packages meet IATA Dangerous Goods Regulations (DGR) for organic peroxides.

Shipping Modes:

Expedited: 3–5 business days (e.g., DHL Express) for time-sensitive research projects.

Standard: 7–14 days via sea freight, cost-effective for bulk orders.
emperature & Stability Control

Storage Conditions:

Pre-Shipment: Store at 2–8°C if light-sensitive; avoid freezing to prevent crystallization.

In Transit: Maintain ambient temperature (15–25°C) with humidity <60%. Use data loggers for real-time monitoring.

Risk Mitigation: Include desiccants and oxygen absorbers in packaging. Avoid prolonged exposure to sunlight or electromagnetic fields.

Q1: What is the primary function of Olivetolic Acid?

A: Olivetolic acid is the fundamental biosynthetic precursor in the cannabinoid pathway. It is the key natural starting material for the enzymatic or synthetic production of Cannabidiolic Acid (CBDA), which decarboxylates to form Cannabidiol (CBD), and other major cannabinoids.

Q2: How is your Olivetolic Acid produced? Is it natural or synthetic?

A: We offer fermentation-derived Olivetolic acid produced using advanced biosynthesis techniques. This method provides a scalable, consistent, and sustainable supply of a nature-identical molecule, avoiding the complexities and low yields of traditional plant extraction.

Q3: What purity do you offer, and how is it verified?

A: We supply high-purity grades, typically ≥95% and ≥98%, verified by orthogonal analytical methods including HPLC-DAD, GC-MS, and NMR spectroscopy. A detailed Certificate of Analysis (CoA) is provided with every batch.

Q4: Is this product suitable for pharmaceutical R&D?

A: Yes. Our Pharmaceutical Grade Olivetolic acid is manufactured and controlled to high standards, making it an ideal GMP starting material for the development of cannabinoid-based Active Pharmaceutical Ingredients (APIs) and finished dosage forms.

Q5: What are the shipping and storage requirements?

A: The product is shipped at ambient temperature. For long-term storage, we recommend keeping it in the original sealed container at -20°C and protected from light to maximize stability. It is stable under these conditions for extended periods.

Q6: Is Olivetolic Acid a controlled substance?

A: No. Olivetolic acid itself is not a controlled substance under the international drug conventions (UN Single Convention on Narcotic Drugs). It is a natural biosynthetic intermediate. However, regulations can vary by country, and it is the customer's responsibility to ensure compliance with their local import and use regulations.

Q7: Can you supply this compound under a Quality Agreement?

A: Absolutely. We routinely work with pharmaceutical clients and can manufacture under a Quality Agreement that specifies testing methods, quality attributes, and change control procedures to ensure full regulatory compliance for your projects.

Q8: Do you offer custom synthesis for Olivetolic Acid analogs?

A: Yes. Our expertise in biosynthetic pathways allows us to explore the production of custom analogs and derivatives (e.g., with different alkyl chain lengths). Please contact our business development team to discuss your specific project requirements.

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