5-Heptylresorcinol (CAS No.500-67-4) is a multifunctional compound with applications in pharmaceuticals, cosmetics, and biotechnology. Its antioxidant, cannabinoid-like, and mitochondrial-protective properties position it as a promising candidate for developing novel therapeutics and nutraceuticals.
Name :
5-HeptylresorcinolCAS No. :
500-67-4MF :
C₁₃H₂₀O₂MW :
208.3Purity :
99%Appearance :
Off white solid powderStorage Condition :
Stable under recommended storage conditions (refrigerated, inert atmosphere)Chemical Properties
CAS Number: 500-67-4
IUPAC Name: 5-Heptylresorcinol
Synonyms: 5-Heptylbenzene-1,3-diol; 1,3-Dihydroxy-5-heptylbenzene
Molecular Formula: C₁₃H₂₀O₂
Molecular Weight: 208.30 g/mol
Appearance: Off white solid powder
Solubility:
•Soluble in ethanol, methanol, DMSO, ethyl acetate
•Insoluble in water (log P ~5.2, high lipophilicity)
Key Functional Groups:
•Resorcinol core (meta-dihydroxybenzene)
•Linear heptyl chain (-C₇H₁₅)
Key Functional Properties
| Property | Mechanism/Value | Application Relevance |
| Antioxidant | Radical scavenging (IC₅₀ ~10 μM vs. DPPH) | Prevents lipid oxidation in formulations |
| Antimicrobial | Disrupts microbial membranes (MIC: 25-50 μg/mL vs. S. aureus) | Natural preservative |
| Antifungal | Inhibits fungal biofilms | Crop protection, material coatings |
| Tyrosinase Inhibition | 80-90% inhibition at 100 μM | Skin brightening/cosmetic depigmentation |
| Surfactant-like | Amphiphilic structure | Emulsion stabilization |
Applications
A. Cosmetics & Personal Care
•Primary Use: Skin-brightening agent (superior to kojic acid in melanin suppression)
•Formulations: Serums, creams, whitening lotions (use level: 0.1-1.0%)
•Advantages: Non-cytotoxic at effective doses (<0.5 mg/mL), photostable, compatible with vitamin C.
B. Food Preservation
•Function: Natural alternative to BHA/BHT
•Applications:
•Edible coatings for fruits/meats
•Antioxidant booster in oils (extends shelf-life 2.3× vs. control)
C. Agriculture
•Biofouling Control: Marine antifouling coatings (inhibits barnacle adhesion)
•Plant Protection: Fungicidal sprays against Botrytis cinerea(EC₅₀: 12 μg/mL)
D. Pharmaceutical Research
•Target: Cannabinoid receptor analogs (heptyl chain mimics alkylpharmacophore)
•Status: Preclinical investigational compound.
Safety & Regulatory Status
•Toxicity Profile:
•LD₅₀ (rat oral): >2,000 mg/kg
•Skin irritation: Mild (OECD 404)
•Non-mutagenic (Ames test)
•Regulatory:
•Cosmetic Use: Approved in EU/Asia (not yet FDA-monographed)
•Storage: Stable at -20°C (desiccated); shelf-life >2 years.
•Handling: Use PPE (gloves, goggles); avoid inhalation.
Our Advantage
Reducing energy consumption by 20% compared to industry averages.
Shipment Guidelines
Labeling: Include hazard symbols CAS number, and "Keep Away from Heat/Incompatible Substances" warnings.
Air Freight: Preferred for urgent shipments; ensure packages meet IATA Dangerous Goods Regulations (DGR) for organic peroxides .
Shipping Modes:
Expedited: 3–5 business days (e.g., DHL Express) for time-sensitive research projects.
Standard: 7–14 days via sea freight, cost-effective for bulk orders.
Storage Conditions:
Pre-Shipment: Store at 2–8°C if light-sensitive; avoid freezing to prevent crystallization.
In Transit: Maintain ambient temperature (15–25°C) with humidity <60%. Use data loggers for real-time monitoring.
Risk Mitigation: Include desiccants and oxygen absorbers in packaging. Avoid prolonged exposure to sunlight or electromagnetic fields.
FAQ
Q1: What is the main application of this compound?
A: It is primarily used as a high-performance skin brightening agent in cosmetics and a natural preservative in formulations. Its heptyl chain provides enhanced lipid solubility and bioactivity compared to shorter-chain analogs.
Q2: How does it work for skin brightening?
A: It acts as a potent tyrosinase inhibitor (85-90% inhibition at 100 μM), effectively reducing melanin production. The heptyl chain improves skin penetration and duration of action.
Q3: What purity grades are available?
A: We supply:
•Cosmetic Grade: ≥98% (HPLC)
•Research Grade: ≥99% (HPLC with NMR confirmation)
All batches include full Certificate of Analysis with heavy metal and residual solvent testing.
Q4: Is it approved for cosmetic use globally?
A: It is compliant with EU Cosmetics Regulation (EC 1223/2009). Status in other regions (US FDA, China NMPA) requires customer verification. We provide compliance documentation for EU applications.
Q5: Can it replace synthetic preservatives?
A: Yes. It shows broad-spectrum antimicrobial activity (MIC 25-50 μg/mL against bacteria/fungi) and antioxidant properties, making it suitable for "clean label" formulations.
Q6: What's the recommended usage concentration?
A: •Skin brightening: 0.1-0.5%
•Preservation: 0.2-0.8%
Always conduct compatibility testing with your formulation base.
Q7: How should it be stored?
A: Store in sealed containers at -20°C under inert atmosphere. Stable for 24+ months with proper handling.
Q8: Do you offer custom chain length variations?
A: Yes. We provide:
•C5-C9 alkyl chain analogs
•Bulk quantities (kg-scale)
•Formulation support for specific applications
Q9: What documentation do you provide?
A: All shipments include:
•Certificate of Analysis (HPLC, NMR, heavy metals)
•Stability data
•Material Safety Data Sheet (GHS compliant)
•Regulatory support documents
Q10: Is this compound safe for topical use?
A: When used within recommended concentrations, it shows excellent safety profile (LD₅₀ >2000 mg/kg oral rat). Non-irritating at use levels per OECD 404 guidelines. Always patch-test in final formulations.
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