Divarin(CAS No.500-49-2) also known as 5-Propylresorcinol, is a member of the alkylresorcinol family with significant bioactive properties. The language is tailored to attract researchers in the food, cosmetic, and pharmaceutical industries.
Name :
DivarinCAS No. :
500-49-2MF :
C₉H₁₂O₂MW :
152.19Purity :
97%Appearance :
White to pale yellow crystalline solid or off-white powderStorage Condition :
Store in a cool, dry place away from oxidizersChemical Properties
|
Formal Name |
5-Propyl-1,3-benzenediol |
|
Synonyms |
Divarin;Divarinol;5-Propylresorcinol; 1,3-Dihydroxy-5-propylbenzene |
|
CAS Number |
500-49-2 |
|
Molecular Formula |
C₉H₁₂O₂ |
|
Formula Weight |
152.19 g/mol |
Structure:
Core Structure: A resorcinol derivative (1,3-dihydroxybenzene) with a propyl chain (-CH₂CH₂CH₃) attached at the 5-position of the benzene ring.
SMILES Notation: C1(O)=CC(CCC)=CC(O)=C1
Physical Characteristics:
Appearance:White to pale yellow crystalline solid or off-white powder
Melting point:82.8°C
Boiling point: ~234.66°C (estimated)
pKa: 9.56 ± 0.10 (predicted)
Solubility: Sparingly soluble in water; soluble in ethanol, DMF, DMSO, and ethyl acetate
Natural Sources & Synthesis
Natural Occurrence: Found in plants like Lithospermum erythrorhizonand Rosaspecies
Synthesis Pathway:
Sulfonation: React benzene with fuming sulfuric acid to form diphenyl sulfone.
Alkylation: Introduce propyl groups via Friedel-Crafts alkylation.
Hydroxylation: Introduce hydroxyl groups at positions 1 and 3 using oxidative agents
Key Raw Materials:
Benzene, propyl bromide, sulfuric acid, and hydrobromic acid
Purity: Commercially available at 97–99%
Biological Activities
Antifungal: Inhibits Candida albicansand Trichophyton mentagrophytes
Antioxidant: Reduces lipid peroxidation in cell cultures
TRPV4 Activation: Stimulates thermosensitive transient receptor potential (TRPV4) channels, modulating intracellular calcium levels (EC₅₀: 0.9–6.4 μM)
Antiviral: Inhibits viral reverse transcriptase and protease enzymes
Applications
Pharmaceutical Intermediate:
Precursor for Cannabigerovarin (CBGV), a cannabinoid with therapeutic potential in pain management and neuroprotection
Investigated for anti-inflammatory and neuroprotective therapies
Industrial Uses:
Antioxidant in rubber and coatings
Preservative in cosmetics and pharmaceuticals
Our Advantage
Reducing energy consumption by 20% compared to industry averages.
Shipment Guidelines
Labeling: Include hazard symbols CAS number, and "Keep Away from Heat/Incompatible Substances" warnings.
Air Freight: Preferred for urgent shipments; ensure packages meet IATA Dangerous Goods Regulations (DGR) for organic peroxides.
Shipping Modes:
Expedited: 3–5 business days (e.g., DHL Express) for time-sensitive research projects.
Standard: 7–14 days via sea freight, cost-effective for bulk orders.
Storage Conditions:
Pre-Shipment: Store at 2–8°C if light-sensitive; avoid freezing to prevent crystallization.
In Transit: Maintain ambient temperature (15–25°C) with humidity <60%. Use data loggers for real-time monitoring.
Risk Mitigation: Include desiccants and oxygen absorbers in packaging. Avoid prolonged exposure to sunlight or electromagnetic fields.
FAQ
Q1: What is the primary application of this compound?
A: It is a versatile bioactive compound primarily used as a potent antioxidant and antimicrobial agent in cosmetic formulations. It also functions as a key synthetic intermediate in pharmaceutical and organic chemistry research.
Q2: How does it function in cosmetic products?
A: In cosmetics, it acts through multiple mechanisms:
•Antioxidant: Neutralizes free radicals to prevent oxidative damage
•Antimicrobial: Provides broad-spectrum protection against bacteria and fungi
•Stabilizer: Extends product shelf-life by preventing degradation
Q3: What purity grades are available?
A: We offer:
•Standard Grade: ≥97% purity
•High Purity Grade: ≥99% purity
All batches include HPLC and NMR verification with complete Certificate of Analysis (CoA).
Q4: Is this compound approved for cosmetic use?
A: Yes, it complies with EU Cosmetics Regulation (EC No 1223/2009) and is suitable for topical applications. However, final formulation compliance is the customer's responsibility.
Q5: What's the recommended storage condition?
A: Store in tightly sealed containers at -20°C under inert atmosphere. Protect from light and moisture to maintain stability.
Q6: Can you provide custom synthesis services?
A: Absolutely. We offer:
•Structural analogs with different alkyl chain lengths
•Bulk quantities (kg-scale)
•Customized packaging solutions
Contact our synthesis team with specific requirements.
Q7: What's the minimum order quantity?
A:•R&D samples: 1-5 grams
•Standard orders: 25 grams minimum
•Bulk production: Kilogram quantities (4-6 week lead time)
Q8: Is this compound suitable for food applications?
A: While it shows promise as a natural preservative, regulatory status varies by jurisdiction. Customers must verify compliance with local food safety regulations (FDA, EFSA, etc.) before use in food products.
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