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99% Purity L(+)-Choline bitartrate CAS 87-67-2​

99% Purity L(+)-Choline bitartrate CAS 87-67-2​

L(+)-Choline bitartrate CAS 87-67-2​ is an organic salt compound formed from one molecule of choline (a quaternary ammonium cation and essential nutrient) and one molecule of L(+)-tartaric acid (a natural dicarboxylic acid). It is a specific, enantiomerically pure form of choline salt where the counterion is derived from natural tartaric acid.It is a high-purity, stable, and highly bioavailable source of essential choline, combining the vital nutrient with a natural, food-grade organic acid. It offers a superior balance of safety, solubility, and cost-effectiveness​ for dietary supplementation and food fortification.

 

 

  • Name :

    L(+)-Choline bitartrate
  • CAS No. :

    87-67-2​
  • MF :

    C₉H₁₉NO₇
  • MW :

    253.25
  • Purity :

    99%
  • Appearance :

    White, crystalline, hygroscopic powder
  • Storage Condition :

    Store in a ​tightly sealed container in a cool, dry place.

Chemical Properties

IUPAC Name:​​ (2-Hydroxyethyl)trimethylammonium; (2R,3R)-2,3-dihydroxybutanedioate

​Chemical Formula:​​ C₉H₁₉NO₇ (C₅H₁₄NO⁺ • C₄H₅O₆⁻)

​Molecular Weight:​​ 253.25 g/mol

​Structure:​​ Consists of a choline cation [(CH₃)₃N⁺CH₂CH₂OH] ionically bonded to a bitartrate anion [HOOC-CH(OH)-CH(OH)-COOH]. The "L(+)" denotes the specific stereoisomer of tartaric acid used (the naturally occurring form).

​Appearance:​​ White, crystalline, hygroscopic powder with a characteristic acidic taste.

​Melting Point:​​ Decomposes before melting, typically around 150-160°C.

​Solubility:​​ ​Highly soluble in water​ (~150 g/100 mL). Sparingly soluble in ethanol and insoluble in non-polar organic solvents (ether, chloroform). The high water solubility is a key functional advantage.

​Stability:​​ Stable under normal storage conditions but ​hygroscopic​ (absorbs moisture from air). Aqueous solutions are stable at acidic pH but choline can undergo degradation (e.g., to trimethylamine, causing a "fishy" odor) in alkaline conditions or upon prolonged exposure to high heat and moisture.

​pH:​​ An aqueous solution is weakly acidic (pH ~3.0-3.5), due to the tartaric acid component.

​Choline Content:​​ Contains approximately ​41% choline by weight. This is a critical specification for dosage calculations.

 

Biological Activities

Essential Nutrient Function:​​ Choline is a ​vital, vitamin-like essential nutrient. It serves as:

1.A precursor for the neurotransmitter ​acetylcholine, critical for memory, mood, muscle control, and nervous system function.

2.A precursor for ​phosphatidylcholine, a major structural phospholipid in all cell membranes.

3.A source of ​methyl groups​ via its metabolite betaine, involved in homocysteine metabolism and liver health.

​Bioavailability:​​ The bitartrate salt provides choline in a highly bioavailable, water-soluble form. The tartaric acid component may aid in absorption and stability.

​Deficiency & Health Impact:​​ Inadequate choline intake can lead to fatty liver (hepatic steatosis), muscle damage, and cognitive impairments. It is particularly critical during pregnancy for fetal brain development.

Safety & Toxicity:​​ Very low acute toxicity. The ​Tolerable Upper Intake Level (UL)​​ for adults is 3.5 g/day of choline. Excessive intake can cause side effects like hypotension, fishy body odor (from trimethylamine), sweating, and gastrointestinal distress.

 

Biosynthesis

Endogenous Synthesis:​​ The human body synthesizes some choline in the liver via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, but this is insufficient to meet total needs, making dietary intake essential.

​Industrial Synthesis:​​ Produced commercially via chemical synthesis.

​1.Choline Production:​​ Typically involves the reaction of ​trimethylamine​ with ​ethylene oxide​ to form choline base, which is then neutralized.

​2.Salt Formation:​​ The choline base (often as choline hydroxide solution) is reacted with a stoichiometric equivalent of ​L(+)-tartaric acid. The "L(+)" specifies the natural isomer derived from natural sources like grapes.

​3.Purification:​​ The resulting salt is crystallized, washed, and dried to a fine powder, meeting food or pharmaceutical grade standards.

 

Applications

  • #
    Dietary Supplements & Nootropics
    The ​primary application. Used in standalone choline supplements, brain health formulas, prenatal vitamins, and liver support products to boost choline intake and support cognitive function, liver health, and fetal development.
  • #
    Functional Foods & Beverages
    Added to energy drinks, vitamin waters, sports nutrition products, and fortified foods as a source of choline, often marketed for mental focus and cellular health benefits.
  • #
    Animal Nutrition
    An important additive in livestock, poultry, and aquaculture feed to promote growth, liver function, and fat metabolism.
  • #
    Cosmetics
    Used in some skincare formulations for its purported moisturizing and barrier-strengthening properties as a component of phospholipids.

 

Key Advantages & Benefits

1. Superior Stability & Non-Hygroscopic Handling

Benefit:​ Unlike choline chloride, which is extremely hygroscopic and corrosive, the bitartrate salt is a dry, free-flowing crystalline powder​ that is significantly less prone to absorbing moisture. This ensures longer shelf life, easier handling in manufacturing, and prevents caking in encapsulated or tableted products.

Application Scenario:​ In a high-speed capsule filling operation​ for a nootropic supplement, L(+)-Choline Bitartrate flows smoothly through powder feeders without clumping, ensuring accurate and consistent dosage in every capsule. This eliminates production downtime caused by equipment corrosion or clogging associated with choline chloride.

2. Excellent Solubility with Palatable Acidity

Benefit:​ It is highly soluble in water, making it ideal for liquid formulations. The natural tartaric acid component provides a pleasant, tart taste that can be easily masked or leveraged in flavored products, unlike the intensely bitter or salty taste of other choline salts.

Application Scenario:​ When formulating a caffeine-free, cognitive support drink mix, the product developer uses L(+)-Choline Bitartrate. It dissolves completely in water without sediment, and its mild tartness complements citrus flavor profiles, eliminating the need for additional acidulants and enhancing consumer acceptability.

3. Guaranteed Purity and Defined Composition

Benefit:​ As a specific chemical entity with a defined molecular weight, it allows for precise dosage calculation​ (containing ~41% elemental choline by weight). The "L(+)" designation confirms the use of natural tartaric acid, aligning with clean-label trends and avoiding undefined mixtures.

Application Scenario:​ A pharmaceutical company developing a prenatal vitamin​ requires exact choline content for clinical dosing and labeling. Using L(+)-Choline Bitartrate provides a reliable and consistent source, simplifying regulatory compliance and ensuring each tablet delivers the specified 250 mg of choline as required for maternal health claims.

4. Cost-Effective Bioavailability

Benefit:​ It provides bioavailable choline at a significantly lower cost per gram of active nutrient​ compared to advanced, phospholipid-bound forms like Alpha-GPC or Citicoline, making it the most economical choice for raising systemic choline levels.

Application Scenario:​ For a mass-market multivitamin or a livestock feed premix​ where broad-spectrum nutrient sufficiency at scale is the goal, L(+)-Choline Bitartrate delivers the essential choline activity needed to support basic metabolic and neurological functions without the premium cost of specialized delivery systems.

 

FAQs

Q1: What are the main benefits of taking L(+)-Choline Bitartrate?​​

​A:​​ It is taken primarily to ​support cognitive functions​ (memory, focus) by providing the raw material for acetylcholine, to ​promote liver health​ by preventing fat accumulation, and to ​support cellular structure and signaling. For pregnant women, it is crucial for fetal brain development.

​Q2: How does it compare to other choline sources like Alpha-GPC or Citicoline (CDP-Choline)?​​

​A:​​ It is a ​cost-effective, high-purity source of choline​ but is considered a "base" form. ​Alpha-GPC and Citicoline​ are often called "premium" forms because they may cross the blood-brain barrier more efficiently and also provide components that integrate directly into phospholipid metabolism. Bitartrate is excellent for raising overall choline levels; Alpha-GPC/Citicoline may be preferred for targeted cognitive enhancement.

​Q3: Is this form suitable for vegans/vegetarians?​​

​A: Typically, yes.​​ Most commercially available L(+)-Choline Bitartrate is synthesized chemically and does not involve animal derivatives. The "L(+)" refers to the stereoisomer of tartaric acid, which is usually produced via microbial fermentation of carbohydrates (e.g., from grapes). However, it's always best to verify with the supplier.

​Q4: What is a typical dosage, and are there any side effects?​​

​A:​​

​Dosage:​​ Depends on goals. General supplementation ranges from ​250 mg to 1000 mg daily​ (providing ~100-400 mg of choline). Always follow product labels or a healthcare provider's advice.

​Side Effects:​​ At recommended doses, it is very well-tolerated. High doses (near/exceeding the 3.5g UL) can cause ​fishy body odor, nausea, diarrhea, sweating, or low blood pressure.

​Q5: How should it be stored to maintain potency?​​

​A:​​ Due to its ​hygroscopic​ nature, store in a ​tightly sealed container in a cool, dry place. Avoid exposure to high humidity. Properly stored, it has a shelf life of 2-3 years. Discard if it develops a strong fishy odor, indicating degradation.

​Q6: Can it be combined with other supplements?​​

​A: Yes, synergistically.​​

With ​B Vitamins (especially B5, B9, B12):​​ B5 is a cofactor for acetylcholine synthesis; B9/B12 work with choline/betaine in methylation cycles.

With ​Nootropics like racetams:​​ Often taken together as choline is a rate-limiting precursor for acetylcholine, which some racetams are believed to modulate.

With ​Liver support supplements (e.g., milk thistle):​​ For comprehensive liver health.

​Q7: Are there any specific populations who should be cautious?​​

​A:​​ Individuals with ​kidney or liver disease​ should consult a doctor before use, as altered metabolism may be a concern. Those with ​trimethylaminuria​ (disorder causing fishy odor) may experience worsened symptoms. ​Pregnant and breastfeeding women​ are encouraged to ensure adequate choline intake but should do so under medical guidance.

 

 

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